Defining the Healthy Human Microbiome
Billions of Genes and Counting!
The Biosciences Computing Group (BCG) is part of the Computational Research Division (CRD) at DOE’s Lawrence Berkeley National Laboratory (LBNL). BCG's mission is to address key data management challenges caused by the massive increase in the amount and range of biological data, the difficulty of quantifying the quality of data generated using inherently imprecise tools and techniques, and the high complexity of integrating data residing in diverse and sometimes poorly correlated repositories. BCG's strategy involves using existing database technologies and analysis methods, adapted as needed to a specific application, in order to address immediate biological data management and bioinformatics requirements. Critical data management and analysis problems that cannot be resolved using existing technologies and methods are pursued as part of longer term R&D activities.
In partnership with scientists of the Microbial Genome and Metagenome Programs at the DOE Joint Genome Institute (JGI), BCG engineers and computer scientists have developed and maintained a suite of microbial genome and metagenome data management and analysis systems, called the Integrated Microbial Genomes (IMG) systems. These systems have a large community of scientific users worldwide, and have provided support for the completion of thousands of microbial genome and metagenome studies. BCG’s activities are mainly of a production nature, whereby the key challenges regard the regular content and software updates of the IMG systems while coping with a rapid increase in the number and size of new microbial genome and metagenome datasets.
Co-Group Leads: I-Min Chen and Ken Chu