Berkeley Lab Scientific Computing Seminar

Date:

Friday, October 20, 2006

Time:

1:00pm-2:00pm

Location:

Building 50A-5132

Seminar Speaker:

Philip Sternberg
Department of Mathematics
UC Davis
http://www.math.ucdavis.edu/~sternberg/

Title:

Estimation of Contrast Transfer Function Parameters by Nonlinear Optimization

Abstract:

In recent years, great progress has been made in reconstructing 3-D images of macromolecular assemblies from electron microscopy data. One of the major challenges in this area is to correct for degradation that occurs during the image formation process. This degradation is described by the contrast transfer theory, in which several parameterized functions encode the relationship between the degraded image and its ideal, undegraded counterpart. In this talk, I will present our formulation of the estimation of these parameters as a nonlinear optimization problem, and illustrate a robust method that we developed for solving this problem using a combination of linear and nonlinear programming.

Sponsor of Seminar:

Esmond Ng

Scientific Computing

Contact Esmond G. Ng EGNg@lbl.gov